DiePharmazie 3/2008

All research papers in this issue were presented during the 6th Conference on Retrometabolism Based Drug Design and Targeting, June 3-6, 2007, Göd, Hungary.



Loftsson T, Sigurdsson HH, Konrádsdóttir F, Gísladóttir S, Jansook P, Stefánsson E: Topical drug delivery to the posterior segment of the eye: anatomical and physiological considerations

Original articles

Wu WM, Wu J, Mori N, Buchwald P, Bodor N : Stereoisomers of N-substituted soft anticholinergics and their zwitterionic metabolite based on glycopyrrolate - syntheses and pharmacological evaluations

Tokés B, Száva J, Dusa S, Ferencz L, Vintila A, Donáth-Nagy G: The importance, design and modeling of biodegradable complexats. An extension of the structure-soft character relations

Masungi C, Mensch J, Van Dijck A, Borremans C, Willems B, Mackie C, Noppe M, Brewster ME: Parallel Artificial Membrane Permeability Assay (PAMPA) combined with a 10-day multiscreen Caco-2 cell culture as a tool for assessing new drug candidates

Patthy M, Seres G, Tóth-Sarudy Č, Hazai I, Pallagi I, Simay A, Bodor N: Determination of estredox, a compound with sustained estradiol function, and its impurity profile by HPLC

Brewster ME, Vandecruys R, Verreck G, Peeters J: Supersaturating drug delivery systems: effect of hydrophilic cyclodextrins and other excipients on the formation and stabilization of supersaturated drug solutions

Hidvégi E, Hideg ZS, Somogyi GP: Different reactivities of amphetamines with N-methyl-bis(trifluoroacetamide) in heated gas chromatographic injectors

Latere Dwan'Isa JP, Rouxhet L, Brewster ME, Préat V, Ariën A: Spontaneously self-assembled micelles from poly(ethylene glycol)-b-poly(e-caprolactone-co-trimethylene carbonate) for drug solubilization

Morimoto K, Fukushi N, Chono S, Seki T, Tabata Y: Spermined dextran, a cationized polymer, as absorption enhancer for pulmonary application of peptide drugs

Tack F, Noppe M, Van Dijck A, Dekeyzer N, Van Der Leede BJ, Bakker A, Wouters W, Janicot M, Brewster ME: Delivery of a DNAzyme targeting c-myc to HT29 colon carcinoma cells using a gold nanoparticulate approach

Mori N, Yokooji T, Murakami T: Fate of quinidine, a P-glycoprotein substrate, in the gastrointestinal tract after oral administration in rats

Bocca N, Pileggi A, Molano RD, Marzorati S, Wu W, Bodor N, Ricordi C, Buchwald P: Soft corticosteroids for local immunosuppression: exploring the possibility for the use of loteprednol etabonate for islet transplantation

Vincze Z, Brugos B: Does impairment of renal and hepatic function influence the metabolism of thrombolytics in patients with myocardial infarction?